Journal article
Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control
V Pearson-Dennett, PL Faulkner, B Collie, RA Wilcox, AP Vogel, D Thewlis, A Esterman, MN McDonnell, SC Gandevia, JM White, G Todd
Clinical Neurophysiology | ELSEVIER IRELAND LTD | Published : 2019
Abstract
Objective: The study aim was to determine if use of illicit amphetamines or ecstasy is associated with abnormal excitability of the corticomotoneuronal pathway and manipulation of novel objects with the hand. Methods: Three groups of adults aged 18–50 years were investigated: individuals with a history of illicit amphetamine use, individuals with a history of ecstasy use but minimal use of other stimulants, and non-drug users. Transcranial magnetic stimulation was delivered to the motor cortex and the electromyographic response (motor evoked potential; MEP) was recorded from a contralateral hand muscle. Participants also gripped and lifted a novel experimental object consisting of two strain..
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Awarded by Ramaciotti Foundations
Funding Acknowledgements
This work was supported by the Fay Fuller Foundation (Discovery Fund Research Grant), National Health and Medical Research Council of Australia (SCG holds a Senior Principal Research Fellowship, APV holds a Dementia Fellowship, APP 1135683, DT holds a Career Development Fellowship, ID 1126229), Australian Government (PLF and VPD held an Australian Government Research Training Program Scholarship), Clive and Vera Ramaciotti Foundation (Establishment Grant, ID 2974/2010), and the University of South Australia (PLF held a School of Pharmacy and Medical Sciences - Partial PhD Scholarship, VPD held a University of South Australia Top-Up Scholarship). The funding sources had no involvement in the (i) study design, (ii) collection, analysis, and interpretation of the data, and (iii) writing and submission of the article for publication.